G12 Antibody

G12 Antibody2016-09-05T12:34:05+01:00

The G12 antibody recognizes the 33-mer peptide, which is present in the alpha- gliadin protein that causes celiac disease . The 33-mer peptide is the toxic fragment of gluten that affects celiac patients , the entire gluten protein is not harmful , only this peptide.

The G12 antibody is used in all GlutenTox kits, and was specifically designed to detect this toxic peptide. The G12 antibody detects the QPQLPY sequence , found only in the 33-mer peptide .

GlutenTox Home - Anticuerpo G12


Is oat really gluten free?

Oats are often subject to cross-contamination (in the field and / or during the manufacturing process).

However, even if the oat has been grown and processed carefully, this does not mean that it is always free gluten.

A study from the year 2011 (reference 1) showed that not all oats are equal. All varieties of oats contain avenin, but each one with a different structure, and only some of these varieties are toxic for coeliac patients.

The study used the G12 antibody to analyze several varieties of oats:

  • Three different groups have been identified: Varieties with no toxicity, low toxicity or high toxicity.
  • The strains were introduced into cells of celiac patients, and they responded appropriately : the cells only reacted to toxic varieties of oats.

Therefore, the G12 antibody is the best choice for any company that works with gluten-free oats.

Reference 1: Diversity in oat potential immunogenicity: basis for the selection of oat varieties with no toxicity in coeliac disease. Comino et al., Gut. 2011 Jul;60(7):915-22.